Thrombin spatial distribution determines protein C activation during hemostasis and thrombosis.

Marar, Tanya T; Matzko, Chelsea N; Wu, Jie; Esmon, Charles T; Sinno, Talid; Brass, Lawrence F; Stalker, Timothy J; Tomaiuolo, Maurizio

Thrombin spatial distribution determines protein C activation during hemostasis and thrombosis.

Marar, Tanya T; Matzko, Chelsea N; Wu, Jie; Esmon, Charles T; Sinno, Talid; Brass, Lawrence F; Stalker, Timothy J; Tomaiuolo, Maurizio.

Afiliação

Marar TT; Department of Medicine, University of Pennsylvania, Philadelphia, PA.
Matzko CN; Cardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza Foundation for Hematologic Research, Thomas Jefferson University, Philadelphia, PA.
Wu J; Department of Medicine, University of Pennsylvania, Philadelphia, PA.
Esmon CT; Department of Medicine, University of Pennsylvania, Philadelphia, PA.
Sinno T; Oklahoma Medical Research Foundation, Oklahoma City, OK.
Brass LF; Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA; and.
Stalker TJ; Department of Medicine, University of Pennsylvania, Philadelphia, PA.
Tomaiuolo M; Department of Medicine, University of Pennsylvania, Philadelphia, PA.

Blood ; 139(12): 1892-1902, 2022 03 24.

Article em En | MEDLINE | ID: mdl-34890454

Assuntos

Hemostáticos; Trombose; Animais; Anticoagulantes/farmacologia; Células Endoteliais/metabolismo; Fibrina/metabolismo; Hemostasia; Humanos; Camundongos; Proteína C/farmacologia; Trombina/metabolismo; Trombose/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trombose / Hemostáticos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trombose / Hemostáticos Idioma: En Ano de publicação: 2022 Tipo de documento: Article