The potential pharmacological mechanisms of ß-hydroxybutyrate for improving cognitive functions.
Curr Opin Pharmacol
; 62: 15-22, 2022 02.
Article
em En
| MEDLINE
| ID: mdl-34891124
ABSTRACT
ß-Hydroxybutyl acid (ßOHB), the most prevalent type of ketone in the human body, is involved in the pathogenesis of cognitive disorders, especially Alzheimer's dementia (AD), through a variety of mechanisms, such as enhancing mitochondrial metabolism, regulating signaling molecule, increasing histone acetylation, affecting the metabolism of Aß and Tau proteins, inhibiting inflammation and lipid metabolism, and regulating intestinal microbes. Based on the above findings, clinical drug development in AD has begun to focus on ßOHB.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Alzheimer
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article