CSF neurofilament light chain predicts 10-year clinical and radiologic worsening in multiple sclerosis.
Mult Scler J Exp Transl Clin
; 7(4): 20552173211060337, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-34900328
ABSTRACT
BACKGROUND:
Neurofilament light chain (NfL) is an attractive biomarker of disease activity and progression in MS, but there is a lack in long-term prognostic data.OBJECTIVE:
To test the long-term clinical and radiological prognostic value of cerebrospinal fluid (CSF)-NfL among newly diagnosed patients with MS.METHODS:
Newly diagnosed MS patients where followed prospectively with baseline CSF-NfL and repeated MRI and clinical assessments for up to 10 years. Associations between baseline CSF-NfL and longitudinal MRI and clinical assessments were found by Generalized Estimating Equations analysis.RESULTS:
Forty-two participants were included. CSF-NfL at baseline was significantly associated with the rate of atrophy in globus pallidus (p = 0.009) and hippocampus (p = 0.001) as evaluated by MRI. Baseline volumes of thalamus (ß -0.33; 95% CI -0.57 to -0.10, p = 0.006), T1 (ß 0.28; 95% CI 0.11 to 0.44, p = 0.001) and T2 (ß 0.16; 95% CI 0.04 to 0.27, p = 0.008) lesions and baseline levels of CSF-NfL (ß 0.9; 95% CI 0.3 to 1.5, p = 0.002) significantly predicted EDSS worsening over 10 years. Baseline CSF-NfL gave a comparable prediction to the best MRI volumetric predictors.CONCLUSION:
CSF-NfL predicted the clinical and radiological course of newly diagnosed patients with MS over a 10-year period, underlining its prognostic role.
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MEDLINE
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En
Ano de publicação:
2021
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Article