Parahydrogen hyperpolarization of minimally altered urine samples for sensitivity enhanced NMR metabolomics.
Chem Commun (Camb)
; 58(3): 463-466, 2022 Jan 04.
Article
em En
| MEDLINE
| ID: mdl-34908034
ABSTRACT
Parahydrogen hyperpolarization has been shown to enhance NMR sensitivity in urine analysis by several orders of magnitude if urine samples are prepared by solid phase extraction (SPE). We present a different approach, developed for minimal sample alteration before analysis. Removing SPE from the workflow allows to retain a wider range of metabolites and paves the way towards more universal hyperpolarized NMR metabolomics of low abundance metabolites.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Adenosina
/
Cotinina
/
Extração em Fase Sólida
/
Metabolômica
/
Complexos de Coordenação
/
Irídio
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article