Diversity-oriented routes to thiopeptide antibiotics: total synthesis and biological evaluation of micrococcin P2.
Org Biomol Chem
; 20(9): 1893-1899, 2022 03 02.
Article
em En
| MEDLINE
| ID: mdl-34908070
ABSTRACT
We report the first total synthesis of micrococcin P2 (MP2, 1) by a diversity-oriented route that incorporates a number of refinements relative to earlier syntheses. Biological data regarding the activity of 1 against a range of human pathogens are also provided. Furthermore, we disclose a chemical property of MP2 that greatly facilitates medicinal chemistry work in the micrococcin area and describe a method to obtain MP2 by fermentation in B. subtilis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
/
Compostos de Sulfidrila
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Antibacterianos
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Mycobacterium tuberculosis
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article