MAJOR DEPRESSIVE DISORDER IS ASSOCIATED WITH TYPE 2 DIABETES IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION.
Arq Gastroenterol
; 58(4): 476-482, 2021.
Article
em En
| MEDLINE
| ID: mdl-34909853
ABSTRACT
BACKGROUND:
Major depressive disorder (MDD) is commonly reported in patients with chronic hepatitis C (CHC); however, the factors behind the co-occurrence of these conditions have not been completely clarified yet.OBJECTIVE:
We aimed to evaluate the frequency of mental disorders in CHC patients and to investigate variables associated with MDD.METHODS:
CHC patients (n=151) attending a referral Centre for hepatitis were evaluated using the Mini-International Neuropsychiatry Interview and the Cut-Annoyed-Guilty-Eye (CAGE) Questionnaire. Multivariate analysis was used to evaluate independent covariates associated with current MDD.RESULTS:
Seventy-six (50.3%) patients had, at least, one current psychiatric diagnosis with MDD (33.1%) being the most common. Current MDD was independently associated with age (≤50 yr.) (OR=2.57; 95%CI=1.25-5.29; P=0.01) and type 2 diabetes mellitus (OR=2.80, 95%CI=1.17-6.70; P=0.02). Cirrhosis was associated with type 2 diabetes mellitus (OR=5.09; 95%CI=1.73-15.04; P=0.03) and current alcohol abuse/dependence (OR=2.54; 95%CI=1.04-6.22; P=0.04).DISCUSSION:
MDD is associated with type 2 diabetes in CHC patients. Even in the direct-acting antivirals (DAAs) era, characterized by great perspectives for the first ample cure of a chronic viral infection, we should ensure that the screening for psychiatric disorders takes place in the course of routine clinical care of patients chronically infected with hepatitis C virus.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Hepatite C
/
Hepatite C Crônica
/
Transtorno Depressivo Maior
/
Diabetes Mellitus Tipo 2
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article