Dopamine Neuron Challenge Test for early detection of Parkinson's disease.
NPJ Parkinsons Dis
; 7(1): 116, 2021 Dec 16.
Article
em En
| MEDLINE
| ID: mdl-34916526
ABSTRACT
Diagnosing Parkinson's disease (PD) before the clinical onset proves difficult because the hallmark PD symptoms do not manifest until more than 60% of dopamine neurons in the substantia nigra pars compacta have been lost. Here we show that, by evoking a transient dopamine release and subsequently measuring the levels of dopamine metabolites in the cerebrospinal fluid and plasma, a hypodopaminergic state can be revealed when less than 30% of dopamine neurons are lost in mouse PD models. These findings may lead to sensitive and practical screening and diagnostic tests for detecting early PD in the high-risk population.
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MEDLINE
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En
Ano de publicação:
2021
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Article