A semi-automated, isotope-dilution high-resolution mass spectrometry assay for therapeutic drug monitoring of antidepressants.

Lindner, Johanna M; Vogeser, Michael; Sorg, Katharina; Grimm, Stefanie H.

Afiliação

Lindner JM; Institute of Laboratory Medicine, Hospital of the Ludwig-Maximilians-University Munich, Marchioninistraße 15, 81377 Munich, Germany.
Vogeser M; Institute of Laboratory Medicine, Hospital of the Ludwig-Maximilians-University Munich, Marchioninistraße 15, 81377 Munich, Germany.
Sorg K; Institute of Laboratory Medicine, Hospital of the Ludwig-Maximilians-University Munich, Marchioninistraße 15, 81377 Munich, Germany.
Grimm SH; Institute of Laboratory Medicine, Hospital of the Ludwig-Maximilians-University Munich, Marchioninistraße 15, 81377 Munich, Germany.

Clin Mass Spectrom ; 14 Pt B: 89-98, 2019 Nov.

Article em En | MEDLINE | ID: mdl-34917765

Palavras-chave

Antidepressants; CV, coefficient of variation; EMA, European Medicines Agency; ESI, electrospray ionization; HRMS, high-resolution mass spectrometry; High-resolution mass spectrometry; ISTD, internal standard; LC-MS/MS, liquid chromatography tandem mass spectrometry; LLOD, lower limit of detection; LLOQ, lower limit of quantification; MS, mass spectrometry; QC, quality control sample; TDM, therapeutic drug monitoring; Therapeutic drug monitoring (TDM); TurboFlow technology; UHPLC, ultra high-performance liquid chromatography

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article