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NR4A1 suppresses pyroptosis by transcriptionally inhibiting NLRP3 and IL-1ß and co-localizing with NLRP3 in trans-Golgi to alleviate pathogenic bacteria-induced colitis.
Deng, Zhao; Yang, Zhipeng; Cui, Chenbin; Wei, Hongkui; Wang, Lijia; Tian, Dean; Xiao, Fang; Peng, Jian.
Afiliação
  • Deng Z; Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, P. R. China.
  • Yang Z; Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, P. R. China.
  • Cui C; Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, P. R. China.
  • Wei H; Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, P. R. China.
  • Wang L; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, China.
  • Tian D; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, China.
  • Xiao F; Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, China.
  • Peng J; Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, P. R. China.
Clin Transl Med ; 11(12): e639, 2021 12.
Article em En | MEDLINE | ID: mdl-34923769
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colite / Rede trans-Golgi / Membro 1 do Grupo A da Subfamília 4 de Receptores Nucleares / Piroptose Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colite / Rede trans-Golgi / Membro 1 do Grupo A da Subfamília 4 de Receptores Nucleares / Piroptose Idioma: En Ano de publicação: 2021 Tipo de documento: Article