Smart Nano-PROTACs Reprogram Tumor Microenvironment for Activatable Photo-metabolic Cancer Immunotherapy.
Angew Chem Int Ed Engl
; 61(8): e202114957, 2022 02 14.
Article
em En
| MEDLINE
| ID: mdl-34927316
ABSTRACT
Protease inhibitors can modulate intratumoral metabolic processes to reprogram the immunosuppressive tumor microenvironment (TME), which however suffer from the limited efficacy and off-targeted side effects. We report smart nano-proteolysis targeting chimeras (nano-PROTACs) with phototherapeutic ablation and cancer-specific protein degradation to reprogram the TME for photo-metabolic cancer immunotherapy. This nano-PROTAC has a semiconducting polymer backbone linked with a cyclooxygenase 1/2 (COX-1/2)-targeting PROTAC peptide (CPP) via a cathepsin B (CatB)-cleavable segment. CPP can be activated by the tumor-overexpressed CatB to induce the degradation of COX-1/2 via the ubiquitin-proteasome system. The persistent degradation of COX-1/2 depletes their metabolite prostaglandin E2 which is responsible for activation of immune suppressor cells. Such a smart PROTAC strategy synergized with phototherapy specifically reprograms the immunosuppressive TME and reinvigorates antitumor immunity.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Fármacos Fotossensibilizantes
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Ciclo-Oxigenase 1
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Ciclo-Oxigenase 2
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Imunoterapia
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Neoplasias
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Antineoplásicos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article