Iota-carrageenan extracted from red algae is a potent inhibitor of SARS-CoV-2 infection in reconstituted human airway epithelia.

Bovard, David; van der Toorn, Marco; Schlage, Walter K; Constant, Samuel; Renggli, Kasper; Peitsch, Manuel C; Hoeng, Julia.

Afiliação

Bovard D; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, 2000, Neuchâtel, Switzerland.
van der Toorn M; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, 2000, Neuchâtel, Switzerland.
Schlage WK; Biology Consultant, Max-Baermann-Str. 21, 51429, Bergisch Gladbach, Germany.
Constant S; Epithelix Sarl, 18 Chemin des Aulx, Plan-les-Ouates, 1228, Geneva, Switzerland.
Renggli K; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, 2000, Neuchâtel, Switzerland.
Peitsch MC; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, 2000, Neuchâtel, Switzerland.
Hoeng J; PMI R&D, Philip Morris Products S.A, Quai Jeanrenaud 5, 2000, Neuchâtel, Switzerland.

Biochem Biophys Rep ; 29: 101187, 2022 Mar.

Article em En | MEDLINE | ID: mdl-34931176

Palavras-chave

3D, 3-dimensional; AE, after exposure; ALI, airliquid interface; Airliquid interface; BE, before exposure; Bronchial epithelium; CBF, ciliary beating frequency; COVID-19; COVID19, Coronavirus disease 2019; DMMB, Dimethylmethylene blue; IC, Iota-carrageenan; Iota-carrageenan; LDH, lactate dehydrogenase; MOI, multiplicity of infection; NHBE, normal human bronchial epithelial; Nasal epithelium; Nasal spray; PBS, phosphate-buffered saline; SARS-CoV-2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; SSPL, spike-pseudotyped lentivirus; TEER, transepithelial electrical resistance; hACE2, human angiotensin I-converting enzyme 2

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article