Comprehensive Analysis of the HLA Class I and the HLA Class II Alleles in Patients with Takayasu Arteritis: Relationship with Clinical Patterns and Prognosis
Iran J Immunol
; 18(4): 354-365, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-34931621
ABSTRACT
BACKGROUND:
Takayasu arteritis (TA) is a systemic vasculitis, affecting mainly the aorta and its branches.OBJECTIVE:
To analyze the HLA class I and class II alleles in patients with TA and explore their relationship with clinical and demographic characteristics, and potential significance in prognosis.METHODS:
Twenty-five, unrelated TA patients were genotyped for HLA-A, HLA-B, HLA-C, HLA-DRB1, and the HLA-DQB1 loci. The frequencies of the HLA-A, HLA-B, and the HLA-DRB1 were compared with a control group of 1992, while the HLA-C and the HLA-DQB1 were compared with a group of 159 healthy, unrelated individuals.RESULTS:
Among TA patients, 5/25 (20%) were identified as the HLA-B*52 carriers. There was a significant difference in the HLA-B*52 allele frequency in the TA patients (10%) compared with the healthy controls (1.2%). Moreover, presence of the HLA-B*52 was associated with significantly earlier disease onset, more severe clinical presentations, and a poorer response to treatment. The HLA-C*03 was detected in 32% of patients and was present exclusively in those with a clinically mild form of the TA, indicating a putative protective effect.CONCLUSION:
These findings indicate that the HLA-B*52 allele contributes to a higher susceptibility to the TA whereas the HLA-C*03, can be a protective factor in the TA.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Genes MHC Classe I
/
Genes MHC da Classe II
/
Arterite de Takayasu
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article