Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study.

Rawson, Timothy M; Wilson, Richard C; Moore, Luke S P; Macgowan, Alasdair P; Lovering, Andrew M; Bayliss, Mark; Kyriakides, Mathew; Gilchrist, Mark; Roberts, Jason A; Hope, William W; Holmes, Alison H.

Afiliação

Rawson TM; National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, UK.
Wilson RC; Centre for Antimicrobial Optimisation, Imperial College London, Hammersmith Hospital, London, UK.
Moore LSP; National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, UK.
Macgowan AP; Centre for Antimicrobial Optimisation, Imperial College London, Hammersmith Hospital, London, UK.
Lovering AM; National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, UK.
Bayliss M; Chelsea & Westminster NHS Foundation Trust, London, UK.
Kyriakides M; Central London Community Healthcare NHS Trust, London, UK.
Gilchrist M; Department of Infection Sciences, North Bristol NHS Trust, Southmead Hospital, Bristol, UK.
Roberts JA; Department of Infection Sciences, North Bristol NHS Trust, Southmead Hospital, Bristol, UK.
Hope WW; Department of Infection Sciences, North Bristol NHS Trust, Southmead Hospital, Bristol, UK.
Holmes AH; Department of Infection Sciences, North Bristol NHS Trust, Southmead Hospital, Bristol, UK.

Open Forum Infect Dis ; 8(12): ofab573, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34934774

ABSTRACT

This healthy volunteer study aimed to explore phenoxymethylpenicillin (penicillin-V) pharmacokinetics (PK) to support the planning of large dosing studies in adults. Volunteers were dosed with penicillin-V at steady state. Total and unbound penicillin-V serum concentrations were determined, and a base population PK model was fitted to the data.

Palavras-chave

healthy volunteers; oral dosing; penicillin-V; pharmacokinetics; population PK modeling

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article