Progressive nodular histiocytosis in a 9-year-old boy treated with cobimetinib.
Pediatr Dermatol
; 39(1): 115-118, 2022 Jan.
Article
em En
| MEDLINE
| ID: mdl-34935192
ABSTRACT
Progressive nodular histiocytosis is a rare variant of non-Langerhans cell histiocytosis that affects the skin and mucous membranes and displays a progressive clinical course and poor response to treatment. We describe a case of severe progressive nodular histiocytosis harboring a KRAS p.G12S mutation in a 9-year-old boy, refractory to chemotherapy, who was successfully treated with the MEK inhibitor cobimetinib. This is the first report of the use of MEK inhibition for this histiocytosis subtype in a pediatric patient.
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Base de dados:
MEDLINE
Assunto principal:
Dermatopatias
/
Azetidinas
/
Histiocitose
/
Histiocitose de Células de Langerhans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article