Brain Penetrant, but not Peripherally Restricted, Synthetic Cannabinoid 1 Receptor Agonists Promote Morphine-Mediated Respiratory Depression.

Wiese, Beth M; Liktor-Busa, Erika; Couture, Sarah A; Nikas, Spyros P; Ji, Lipin; Liu, Yingpeng; Makriyannis, Alexandros; Spigelman, Igor; Vanderah, Todd W; Largent-Milnes, Tally M

Wiese, Beth M; Liktor-Busa, Erika; Couture, Sarah A; Nikas, Spyros P; Ji, Lipin; Liu, Yingpeng; Makriyannis, Alexandros; Spigelman, Igor; Vanderah, Todd W; Largent-Milnes, Tally M.

Afiliação

Wiese BM; Department of Pharmacology, University of Arizona, Tucson, Arizona, USA.
Liktor-Busa E; Department of Pharmacology, University of Arizona, Tucson, Arizona, USA.
Couture SA; Department of Pharmacology, University of Arizona, Tucson, Arizona, USA.
Nikas SP; Chemistry and Chemical Biology, Bouve College Health Sciences-Center for Drug Discovery, Northeastern University, Boston, Massachusetts, USA.
Ji L; Chemistry and Chemical Biology, Bouve College Health Sciences-Center for Drug Discovery, Northeastern University, Boston, Massachusetts, USA.
Liu Y; Chemistry and Chemical Biology, Bouve College Health Sciences-Center for Drug Discovery, Northeastern University, Boston, Massachusetts, USA.
Makriyannis A; Chemistry and Chemical Biology, Bouve College Health Sciences-Center for Drug Discovery, Northeastern University, Boston, Massachusetts, USA.
Spigelman I; Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, California, USA.
Vanderah TW; Department of Pharmacology, University of Arizona, Tucson, Arizona, USA.
Largent-Milnes TM; Comprehensive Pain and Addiction Center, University of Arizona, Health Sciences, Tucson, Arizona, USA.

Cannabis Cannabinoid Res ; 7(5): 621-627, 2022 10.

Article em En | MEDLINE | ID: mdl-34935460

Assuntos

Canabinoides; Insuficiência Respiratória; Humanos; Morfina/efeitos adversos; Agonistas de Receptores de Canabinoides/farmacologia; Analgésicos Opioides/efeitos adversos; Endocanabinoides; Canabinoides/efeitos adversos; Morfolinas/farmacologia; Encéfalo; Insuficiência Respiratória/induzido quimicamente; Receptores de Canabinoides

Palavras-chave

cannabinoid receptor 1; mu opioid receptor; opioid-induced respiratory depression; synthetic cannabinoid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Insuficiência Respiratória / Canabinoides Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Insuficiência Respiratória / Canabinoides Idioma: En Ano de publicação: 2022 Tipo de documento: Article