Mechanistic diversity in MHC class I antigen recognition.
Biochem J
; 478(24): 4187-4202, 2021 12 22.
Article
em En
| MEDLINE
| ID: mdl-34940832
ABSTRACT
Throughout its evolution, the human immune system has developed a plethora of strategies to diversify the antigenic peptide sequences that can be targeted by the CD8+ T cell response against pathogens and aberrations of self. Here we provide a general overview of the mechanisms that lead to the diversity of antigens presented by MHC class I complexes and their recognition by CD8+ T cells, together with a more detailed analysis of recent progress in two important areas that are highly controversial the prevalence and immunological relevance of unconventional antigen peptides; and cross-recognition of antigenic peptides by the T cell receptors of CD8+ T cells.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Receptores de Antígenos de Linfócitos T
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Antígenos de Histocompatibilidade Classe I
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Modelos Imunológicos
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Linfócitos T CD8-Positivos
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Antígenos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article