Organ-on-a-Chip for Studying Gut-Brain Interaction Mediated by Extracellular Vesicles in the Gut Microenvironment.
Int J Mol Sci
; 22(24)2021 Dec 16.
Article
em En
| MEDLINE
| ID: mdl-34948310
ABSTRACT
Extracellular vesicles (EVs) are a group of membrane vesicles that play important roles in cell-to-cell and interspecies/interkingdom communications by modulating the pathophysiological conditions of recipient cells. Recent evidence has implied their potential roles in the gut-brain axis (GBA), which is a complex bidirectional communication system between the gut environment and brain pathophysiology. Despite the evidence, the roles of EVs in the gut microenvironment in the GBA are less highlighted. Moreover, there are critical challenges in the current GBA models and analyzing techniques for EVs, which may hinder the research. Currently, advances in organ-on-a-chip (OOC) technologies have provided a promising solution. Here, we review the potential effects of EVs occurring in the gut environment on brain physiology and behavior and discuss how to apply OOCs to research the GBA mediated by EVs in the gut microenvironment.
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MEDLINE
Assunto principal:
Encéfalo
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Trato Gastrointestinal
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Microambiente Celular
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Vesículas Extracelulares
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Eixo Encéfalo-Intestino
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article