Differences in complications between hepatitis B-related cirrhosis and alcohol-related cirrhosis.
Open Med (Wars)
; 17(1): 46-52, 2022.
Article
em En
| MEDLINE
| ID: mdl-34950772
ABSTRACT
OBJECTIVES:
This study aimed to investigate the differences in complications between hepatitis B virus (HBV)-related and alcohol-related cirrhoses.METHODS:
Medical records of patients with HBV-related and alcohol-related cirrhoses treated from January 2014 to January 2021 were, retrospectively, reviewed. The unadjusted rate and adjusted risk of cirrhotic complications between the two groups were assessed.RESULTS:
The rates of hepatocellular carcinoma (HCC) and hypersplenism were higher in HBV-related cirrhosis (both P < 0.05), whereas the rates of hepatic encephalopathy (HE) and acute-on-chronic liver failure (ACLF) were higher in alcohol-related cirrhosis (both P < 0.05). After adjusting for potential confounders, HBV-related cirrhotic patients had higher risks of HCC (odds ratio [OR] = 34.06, 95% confidence interval [CI] 4.61-251.77, P = 0.001) and hypersplenism (OR = 2.29, 95% CI 1.18-4.42, P = 0.014), whereas alcohol-related cirrhotic patients had higher risks of HE (OR = 0.22, 95% CI 0.06-0.73, P = 0.013) and ACLF (OR = 0.30, 95% CI 0.14-0.73, P = 0.020).CONCLUSION:
Cirrhotic patients with different etiologies had different types of complications HBV-related cirrhotic patients exhibited increased risks of HCC and hypersplenism and alcohol-related cirrhotic patients more readily developing HE and ACLF.
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Base de dados:
MEDLINE
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En
Ano de publicação:
2022
Tipo de documento:
Article