Emerging concepts in sinonasal tumor research.
Curr Opin Otolaryngol Head Neck Surg
; 30(1): 33-39, 2022 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-34958321
ABSTRACT
PURPOSE OF REVIEW Sinonasal malignancies are rare and understudied, often diagnosed at late stages, and may behave aggressively. This review explores investigative diagnostic, therapeutic, and scientific advances specific to sinonasal undifferentiated carcinoma (SNUC), intestinal-type adenocarcinoma (ITAC), and olfactory neuroblastoma (ONB). RECENT FINDINGS:
A number of studies have recently contributed more robust knowledge of the genetic and molecular landscapes of SNUC, ITAC, and ONB. These analyses have identified SMARCB1 and IDH2 mutations in SNUC, potentially allowing for the tumor's subdivision. Recent studies have also defined a role for induction chemotherapy in SNUC. Somatic mutations for ITAC have been identified and may be potentially targetable with FDA approved therapies. Studies defining the tumor microenvironment for ITAC and ONB have introduced the possibility of immune checkpoint inhibition for these tumor types.SUMMARY:
Studies reviewed here detail promising results of the most current and novel characterization of SNUC, ITAC, and ONB genetic and molecular landscapes, which have informed ongoing therapeutic discovery. With continued multi-institutional efforts, the field of sinonasal tumor research will achieve higher disease control and improved treatment outcomes for patients afflicted with these rare cancers.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Seio Maxilar
/
Neoplasias dos Seios Paranasais
/
Carcinoma
/
Neoplasias Nasais
/
Estesioneuroblastoma Olfatório
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article