Adult lifetime body mass index trajectories and endometrial cancer risk.
BJOG
; 129(9): 1521-1529, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-34962692
ABSTRACT
OBJECTIVE:
To identify body mass index (BMI) trajectories in adult life and to examine their association with endometrial cancer (EC) risk, also exploring whether relations differ by hormonal replacement therapy use.DESIGN:
Pooled analysis of two case-control studies.SETTING:
Italy and Switzerland. POPULATION A total of 458 EC cases and 782 controls.METHODS:
We performed a latent class growth model to identify homogeneous BMI trajectories over six decades of age, with a polynomial function of age. Odds ratios (ORs) and the corresponding 95% CI for EC risk were derived through a multiple logistic regression model, correcting for classification error. MAIN OUTCOMEMEASURES:
The relation of BMI trajectories with endometrial cancer.RESULTS:
We identified five BMI trajectories. Compared with women in the 'Normal weight-stable' trajectory, a reduction by about 50% in the risk of EC emerged for those in the 'Underweight increasing to normal weight' (95% CI 0.28-0.99). The 'Normal weight increasing to overweight' and the 'Overweight-stable' trajectories were associated with, respectively, an excess of 3% (95% CI 0.66-1.60) and of 71% (95% CI 1.12-2.59) in cancer risk. The OR associated to the trajectory 'Overweight increasing to obese' was 2.03 (95% CI 1.31-3.13). Stronger effects emerged among hormonal replacement therapy never users (OR 2.19 for the 'Overweight-stable' trajectory and OR 2.49 for the 'Overweight increasing to obese' trajectory).CONCLUSIONS:
Our study suggests that longer exposure to overweight and obesity across a lifetime is associated with an increased risk of endometrial cancer. Weight during adulthood also appears to play an important role. TWEETABLE ABSTRACT Longer exposure to overweight and obesity across a lifetime is associated with an increased risk of endometrial cancer.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Endométrio
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Sobrepeso
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article