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[Study on the etiological characteristics and prevention and control of adult community-acquired pneumonia in hospitalized patients in a hospital in Beijing from 2015 to 2019].
Wang, M; Zhao, J Y; Li, X; Wu, L Y; Zhou, Q Q; Huang, Y F; Sui, W J; Zhang, S Y; Xu, J; Jin, J M; Gu, H T; Lu, X X.
Afiliação
  • Wang M; Department of Laboratory Medicine,Beijing Tongren Hospital, Capital Medical University,Beijing 100730,China.
  • Zhao JY; Department of Laboratory Medicine,Beijing Shunyi Hospital,Beijing 101300,China.
  • Li X; Department of Laboratory Medicine,Beijing Anding Hospital, Capital Medical University,Beijing 100029, China.
  • Wu LY; Department of Laboratory Medicine, Guangzhou Women and Childrens Medical Center,Guangzhou 510623,China.
  • Zhou QQ; Department of Laboratory Medicine,Beijing Tongren Hospital, Capital Medical University,Beijing 100730,China.
  • Huang YF; Department of Laboratory Medicine,Beijing Tongren Hospital, Capital Medical University,Beijing 100730,China.
  • Sui WJ; Department of Laboratory Medicine,Beijing Tongren Hospital, Capital Medical University,Beijing 100730,China.
  • Zhang SY; Department of Laboratory Medicine,Beijing Tongren Hospital, Capital Medical University,Beijing 100730,China.
  • Xu J; Department of Respiratory Medicine,Beijing Tongren Hospital, Capital Medical University,Beijing 100730,China.
  • Jin JM; Department of Infectious Disease,Beijing Tongren Hospital, Capital Medical University,Beijing 100730,China.
  • Gu HT; Department of Laboratory Medicine,Beijing Tongren Hospital, Capital Medical University,Beijing 100730,China.
  • Lu XX; Department of Laboratory Medicine,Beijing Tongren Hospital, Capital Medical University,Beijing 100730,China.
Zhonghua Yu Fang Yi Xue Za Zhi ; 55(12): 1410-1418, 2021 Dec 06.
Article em Zh | MEDLINE | ID: mdl-34963237
Objective: To explore the distribution characteristics of pathogens in adult patients with community-acquired pneumonia (CAP) and to provide basis for the diagnosis, treatment, prevention of CAP. Methods: 1 446 inpatients with CAP were prospectively enrolled in a third-class hospital in Beijing in recent 5 years (from January 2015 to December 2019). Respiratory tract samples were collected for smear, culture, nucleic acid, antigen and antibody detection to identify the pathogen of CAP. Mann-Whitney U test was used for continuous variables and χ2 test or Fisher's exact test was used for categorical data for statistical analysis. Results: Among the 1 446 patients, 822 (56.85%) patients were infected with a single pathogen, 231 (15.98%) patients were infected with multiple pathogens, and 393 (27.18%) patients were not clear about the pathogen. Influenza virus is the first pathogen of CAP (20.95%, 303/1 446), mainly H1N1 (8.51%, 123/1 446), followed by mycoplasma pneumoniae (7.19%, 104/1 446), Mycobacterium tuberculosis (5.33%, 77/1 446) and Streptococcus pneumoniae (5.05%, 73/1 446). The outbreak of H1N1 occurred from December 2018 to February 2019, and the epidemic of mycoplasma pneumoniae pneumonia was monitored from August to November 2019. Patients under 65 years old had high detection rates of Mycoplasma pneumoniae (14.41% vs. 2.41%, χ²=74.712,P<0.001), Streptococcus pneumoniae (8.16% vs. 2.99%, χ²=18.156, P<0.001), rhinovirus (6.08% vs. 3.56%, χ²=5.025, P<0.025), Chlamydia pneumoniae (5.90% vs. 1.15%, χ²=26.542, P<0.001) and adenovirus (3.13% vs. 0.92%, χ²=9.547, P=0.002). The severe disease rate of CAP was 14.66% (212/1 446), and the average mortality rate was 3.66% (53/1 446). The severe illness rate and mortality rate of bacterial-viral co-infection were 28.97% (31/107) and 19.63% (21/107), respectively. Conclusions: Influenza virus is the primary pathogen of adult CAP. Outbreaks of Mycoplasma pneumoniae and H1N1 were detected in 2018 and 2019, respectively. The remission rate and mortality rate of virus-bacteria co-infection were significantly higher than those of single pathogen infection. Accurate etiological basis not only plays a role in clinical diagnosis and treatment, but also provides important data support for prevention and early warning.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia por Mycoplasma / Chlamydophila pneumoniae / Infecções Comunitárias Adquiridas / Vírus da Influenza A Subtipo H1N1 Idioma: Zh Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia por Mycoplasma / Chlamydophila pneumoniae / Infecções Comunitárias Adquiridas / Vírus da Influenza A Subtipo H1N1 Idioma: Zh Ano de publicação: 2021 Tipo de documento: Article