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GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity.
Heitzeneder, Sabine; Bosse, Kristopher R; Zhu, Zhongyu; Zhelev, Doncho; Majzner, Robbie G; Radosevich, Molly T; Dhingra, Shaurya; Sotillo, Elena; Buongervino, Samantha; Pascual-Pasto, Guillem; Garrigan, Emily; Xu, Peng; Huang, Jing; Salzer, Benjamin; Delaidelli, Alberto; Raman, Swetha; Cui, Hong; Martinez, Benjamin; Bornheimer, Scott J; Sahaf, Bita; Alag, Anya; Fetahu, Irfete S; Hasselblatt, Martin; Parker, Kevin R; Anbunathan, Hima; Hwang, Jennifer; Huang, Min; Sakamoto, Kathleen; Lacayo, Norman J; Klysz, Dorota D; Theruvath, Johanna; Vilches-Moure, José G; Satpathy, Ansuman T; Chang, Howard Y; Lehner, Manfred; Taschner-Mandl, Sabine; Julien, Jean-Phillipe; Sorensen, Poul H; Dimitrov, Dimiter S; Maris, John M; Mackall, Crystal L.
Afiliação
  • Heitzeneder S; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Lorry Lokey Building, Suite G3141, MC: 5456, 265 Campus Drive, Stanford, CA 94305, USA.
  • Bosse KR; Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Zhu Z; National Cancer Institute, Frederick, MD 21702, USA.
  • Zhelev D; University of Pittsburgh Department of Medicine, Pittsburgh, PA 15261, USA.
  • Majzner RG; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Lorry Lokey Building, Suite G3141, MC: 5456, 265 Campus Drive, Stanford, CA 94305, USA.
  • Radosevich MT; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Lorry Lokey Building, Suite G3141, MC: 5456, 265 Campus Drive, Stanford, CA 94305, USA.
  • Dhingra S; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Lorry Lokey Building, Suite G3141, MC: 5456, 265 Campus Drive, Stanford, CA 94305, USA.
  • Sotillo E; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Lorry Lokey Building, Suite G3141, MC: 5456, 265 Campus Drive, Stanford, CA 94305, USA.
  • Buongervino S; Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Pascual-Pasto G; Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Garrigan E; Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Xu P; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Lorry Lokey Building, Suite G3141, MC: 5456, 265 Campus Drive, Stanford, CA 94305, USA.
  • Huang J; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Lorry Lokey Building, Suite G3141, MC: 5456, 265 Campus Drive, Stanford, CA 94305, USA.
  • Salzer B; St. Anna Children's Cancer Research Institute, Vienna, Austria; Christian Doppler Laboratory for Next Generation CAR T Cells, Vienna, Austria.
  • Delaidelli A; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.
  • Raman S; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.
  • Cui H; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.
  • Martinez B; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.
  • Bornheimer SJ; BD Biosciences, San Jose, CA 95131, USA.
  • Sahaf B; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Lorry Lokey Building, Suite G3141, MC: 5456, 265 Campus Drive, Stanford, CA 94305, USA.
  • Alag A; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Lorry Lokey Building, Suite G3141, MC: 5456, 265 Campus Drive, Stanford, CA 94305, USA.
  • Fetahu IS; University of Pittsburgh Department of Medicine, Pittsburgh, PA 15261, USA.
  • Hasselblatt M; Institute of Neuropathology, University Hospital Münster, Münster, Germany.
  • Parker KR; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA.
  • Anbunathan H; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Lorry Lokey Building, Suite G3141, MC: 5456, 265 Campus Drive, Stanford, CA 94305, USA.
  • Hwang J; National Cancer Institute, Frederick, MD 21702, USA.
  • Huang M; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Sakamoto K; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Lacayo NJ; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Klysz DD; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Lorry Lokey Building, Suite G3141, MC: 5456, 265 Campus Drive, Stanford, CA 94305, USA.
  • Theruvath J; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Lorry Lokey Building, Suite G3141, MC: 5456, 265 Campus Drive, Stanford, CA 94305, USA.
  • Vilches-Moure JG; Department of Comparative Medicine, Animal Histology Services, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Satpathy AT; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Chang HY; Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA 94305, USA; Parker Institute for Cancer Immunotherapy, San Francisco, CA 941209, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
  • Lehner M; St. Anna Children's Cancer Research Institute, Vienna, Austria; Christian Doppler Laboratory for Next Generation CAR T Cells, Vienna, Austria.
  • Taschner-Mandl S; St. Anna Children's Cancer Research Institute, Vienna, Austria.
  • Julien JP; Program in Molecular Medicine, Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada; Departments of Biochemistry and Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Sorensen PH; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.
  • Dimitrov DS; University of Pittsburgh Department of Medicine, Pittsburgh, PA 15261, USA.
  • Maris JM; Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Mackall CL; Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Lorry Lokey Building, Suite G3141, MC: 5456, 265 Campus Drive, Stanford, CA 94305, USA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA; Parker Institute for C
Cancer Cell ; 40(1): 53-69.e9, 2022 01 10.
Article em En | MEDLINE | ID: mdl-34971569
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Antígenos de Linfócitos T / Imunoterapia Adotiva / Glipicanas / Neuroblastoma Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Antígenos de Linfócitos T / Imunoterapia Adotiva / Glipicanas / Neuroblastoma Idioma: En Ano de publicação: 2022 Tipo de documento: Article