Prognostic Significance of p16 Protein Expression in Breast Cancer.
In Vivo
; 36(1): 336-340, 2022.
Article
em En
| MEDLINE
| ID: mdl-34972731
ABSTRACT
BACKGROUND/AIM:
Breast cancer is the most common cancer in Sudan. The p16 protein plays a vital role in the regulation of the cell cycle. PATIENTS ANDMETHODS:
This study analysed the protein expression of p16 in 202 paraffin blocks from Sudanese women with breast cancer using immunohistochemistry.RESULTS:
This study included 168 (83.2%), 16 (7.9%), and 18 (8.9%) patients with invasive ductal carcinoma, invasive lobular carcinoma, and papillary carcinoma, respectively. There were 95 cases (47.0%) with grade III, 70 cases (34.6%) with grade II, and 23 cases (11.4%) with grade I breast cancer. The hormone receptor status was available for 119 of the cases, and 31 (15.3%), 25 (12.4%), and 63 (31.2%) cases were positive for oestrogen, progesterone, and HER2 receptors, respectively.CONCLUSION:
p16 protein expression was associated with high histologic grade, lymph node metastasis, and poor prognosis. p16 protein expression may potentially be used as a prognostic marker.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Carcinoma Ductal de Mama
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article