Subcutaneous amyloidoma models for screening potential anti-fibrillating agents in vivo.
STAR Protoc
; 2(4): 101027, 2021 12 17.
Article
em En
| MEDLINE
| ID: mdl-34977673
ABSTRACT
Here, we describe a robust protocol using mouse models to screen potential insulin-stabilizers and insulin moieties. We have generated a mouse model of amyloidoma, found in diabetic patients undergoing insulin therapy. This model can be used to screen potential insulin stabilizers and insulin moieties to prevent amyloidoma formation. This protocol can further be used for the preclinical validation of therapeutically relevant insulin stabilizers and formulations. The protocol highlights all the critical steps for generating amyloidoma in a preclinical model. For complete details on the use and execution of this profile, please refer to Mukherjee et al. (2021).
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Base de dados:
MEDLINE
Assunto principal:
Modelos Animais de Doenças
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Avaliação Pré-Clínica de Medicamentos
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Amiloide
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Amiloidose
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article