Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors <i>In Vitro</i>.

Amano, Masayuki; Yedidi, Ravikiran S; Salcedo-Gómez, Pedro Miguel; Hayashi, Hironori; Hasegawa, Kazuya; Martyr, Cuthbert D; Ghosh, Arun K; Mitsuya, Hiroaki

Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors In Vitro.

Amano, Masayuki; Yedidi, Ravikiran S; Salcedo-Gómez, Pedro Miguel; Hayashi, Hironori; Hasegawa, Kazuya; Martyr, Cuthbert D; Ghosh, Arun K; Mitsuya, Hiroaki.

Afiliação

Amano M; Department of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Hospitalgrid.411152.2, Kumamoto, Kumamoto, Japan.
Yedidi RS; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Salcedo-Gómez PM; The Center for Advanced-Applied Biological Sciences & Entrepreneurship (TCABS-E), Visakhapatnam, Andhra Pradesh, India.
Hayashi H; Department of Zoology, Andhra University, Visakhapatnam, Andhra Pradesh, India.
Hasegawa K; Department of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Hospitalgrid.411152.2, Kumamoto, Kumamoto, Japan.
Martyr CD; Department of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Hospitalgrid.411152.2, Kumamoto, Kumamoto, Japan.
Ghosh AK; Division of Infectious Diseases, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan.
Mitsuya H; Department of Intelligent Network for Infection Control, Tohoku University Graduate School of Medicine, Sendai, Japan.

Antimicrob Agents Chemother ; 66(2): e0171521, 2022 02 15.

Article em En | MEDLINE | ID: mdl-34978889

Assuntos

Inibidores da Protease de HIV; HIV-1; Barreira Hematoencefálica; Sistema Nervoso Central/metabolismo; Flúor/farmacologia; Protease de HIV/metabolismo; Inibidores da Protease de HIV/química; Inibidores da Protease de HIV/farmacologia; Humanos; Replicação Viral

Palavras-chave

HIV-1; HIV-1-associated neurocognitive disorders; blood-brain barrier; central nervous system infections; protease inhibitors

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: HIV-1 / Inibidores da Protease de HIV Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: HIV-1 / Inibidores da Protease de HIV Idioma: En Ano de publicação: 2022 Tipo de documento: Article