Indole-linked 1,2,3-triazole derivatives efficiently modulate COX-2 protein and PGE<sub>2</sub> levels in human THP-1 monocytes by suppressing AGE-ROS-NF-kß nexus.

Jahan, Humera; Siddiqui, Nimra Naz; Iqbal, Shazia; Basha, Fatima Z; Khan, Maria Aqeel; Aslam, Tooba; Choudhary, M Iqbal

Indole-linked 1,2,3-triazole derivatives efficiently modulate COX-2 protein and PGE₂ levels in human THP-1 monocytes by suppressing AGE-ROS-NF-kß nexus.

Jahan, Humera; Siddiqui, Nimra Naz; Iqbal, Shazia; Basha, Fatima Z; Khan, Maria Aqeel; Aslam, Tooba; Choudhary, M Iqbal.

Afiliação

Jahan H; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: humerajahan@iccs.edu.
Siddiqui NN; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Iqbal S; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Basha FZ; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Khan MA; Third World Center for Science and Technology, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Aslam T; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Choudhary MI; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 7

Life Sci ; 291: 120282, 2022 Feb 15.

Article em En | MEDLINE | ID: mdl-34990649

Assuntos

Produtos Finais de Glicação Avançada/metabolismo; Indóis/farmacologia; Triazóis/farmacologia; Ciclo-Oxigenase 2/metabolismo; Citocinas/metabolismo; Dinoprostona/metabolismo; Produtos Finais de Glicação Avançada/efeitos dos fármacos; Humanos; Indóis/química; Inflamação/metabolismo; Mediadores da Inflamação/metabolismo; Monócitos/metabolismo; NF-kappa B/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Células THP-1; Triazóis/química

Palavras-chave

Advanced glycation end products; COX-2; Diabetes; Indole-linked triazoles; Inflammation; Reactive oxygen species

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triazóis / Produtos Finais de Glicação Avançada / Indóis Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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