Coix Seed Diet Ameliorates Immune Function Disorders in Experimental Colitis Mice.
Nutrients
; 14(1)2021 Dec 28.
Article
em En
| MEDLINE
| ID: mdl-35010997
ABSTRACT
Coix seed is a functional food in the Chinese diet that possesses the ability to alleviate ulcerative colitis clinically. However, the underlying mechanisms remain ambiguous. In this study, we investigated the protective effect of the Coix seed diet on experimental colitis mice. The mice were randomly divided into four groups control group, model group, Coix seed feed group, and positive control group. The maintenance feed of the mice was replaced with Coix seed feed 10 days before orally administering the mice 5% (w/v) dextran sulfate sodium drink. As a result, the Coix seed feed alleviated colitis symptoms, maintained the complete blood count at a normal level, reduced the pathological score, relieved inflammatory cytokine secretion, and alleviated oxidative stress. Network pharmacology analysis was used for further exploration of the targets of Coix seed feed. The results showed that T-cell regulation is one of the targets of Coix seed feed, and the analysis of the T-lymphocyte subset and innate immune cell distribution of the colon tissue supported the network pharmacology results. In conclusion, Coix seed, as a staple food, can alleviate experimental colitis, and the mechanism may be related to the immune regulation effect of Coix seeds.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sementes
/
Medicamentos de Ervas Chinesas
/
Colite
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Coix
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Imunidade Inata
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article