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A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.
Hanke, Leo; Das, Hrishikesh; Sheward, Daniel J; Perez Vidakovics, Laura; Urgard, Egon; Moliner-Morro, Ainhoa; Kim, Changil; Karl, Vivien; Pankow, Alec; Smith, Natalie L; Porebski, Bartlomiej; Fernandez-Capetillo, Oscar; Sezgin, Erdinc; Pedersen, Gabriel K; Coquet, Jonathan M; Hällberg, B Martin; Murrell, Ben; McInerney, Gerald M.
Afiliação
  • Hanke L; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Das H; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
  • Sheward DJ; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Perez Vidakovics L; Division of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
  • Urgard E; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Moliner-Morro A; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Kim C; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Karl V; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Pankow A; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Smith NL; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Porebski B; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • Fernandez-Capetillo O; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Sezgin E; Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  • Pedersen GK; Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid, 28029, Spain.
  • Coquet JM; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
  • Hällberg BM; Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark.
  • Murrell B; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
  • McInerney GM; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. martin.hallberg@ki.se.
Nat Commun ; 13(1): 155, 2022 01 10.
Article em En | MEDLINE | ID: mdl-35013189
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anticorpos Biespecíficos / Anticorpos Neutralizantes / Anticorpos de Domínio Único / Glicoproteína da Espícula de Coronavírus / SARS-CoV-2 / COVID-19 / Anticorpos Antivirais Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anticorpos Biespecíficos / Anticorpos Neutralizantes / Anticorpos de Domínio Único / Glicoproteína da Espícula de Coronavírus / SARS-CoV-2 / COVID-19 / Anticorpos Antivirais Idioma: En Ano de publicação: 2022 Tipo de documento: Article