Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis.

Scholz, Markus; Horn, Katrin; Pott, Janne; Gross, Arnd; Kleber, Marcus E; Delgado, Graciela E; Mishra, Pashupati Prasad; Kirsten, Holger; Gieger, Christian; Müller-Nurasyid, Martina; Tönjes, Anke; Kovacs, Peter; Lehtimäki, Terho; Raitakari, Olli; Kähönen, Mika; Gylling, Helena; Baber, Ronny; Isermann, Berend; Stumvoll, Michael; Loeffler, Markus; März, Winfried; Meitinger, Thomas; Peters, Annette; Thiery, Joachim; Teupser, Daniel; Ceglarek, Uta

Scholz, Markus; Horn, Katrin; Pott, Janne; Gross, Arnd; Kleber, Marcus E; Delgado, Graciela E; Mishra, Pashupati Prasad; Kirsten, Holger; Gieger, Christian; Müller-Nurasyid, Martina; Tönjes, Anke; Kovacs, Peter; Lehtimäki, Terho; Raitakari, Olli; Kähönen, Mika; Gylling, Helena; Baber, Ronny; Isermann, Berend; Stumvoll, Michael; Loeffler, Markus; März, Winfried; Meitinger, Thomas; Peters, Annette; Thiery, Joachim; Teupser, Daniel; Ceglarek, Uta.

Afiliação

Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany. markus.scholz@imise.uni-leipzig.de.
Horn K; LIFE Research Center for Civilization Diseases, Medical Faculty, University of Leipzig, Leipzig, Germany. markus.scholz@imise.uni-leipzig.de.
Pott J; Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany.
Gross A; LIFE Research Center for Civilization Diseases, Medical Faculty, University of Leipzig, Leipzig, Germany.
Kleber ME; Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany.
Delgado GE; LIFE Research Center for Civilization Diseases, Medical Faculty, University of Leipzig, Leipzig, Germany.
Mishra PP; Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany.
Kirsten H; Medical Faculty Mannheim, Vth Department of Medicine, Heidelberg University, Heidelberg, Germany.
Gieger C; Medical Faculty Mannheim, Vth Department of Medicine, Heidelberg University, Heidelberg, Germany.
Müller-Nurasyid M; Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland.
Tönjes A; Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany.
Kovacs P; LIFE Research Center for Civilization Diseases, Medical Faculty, University of Leipzig, Leipzig, Germany.
Lehtimäki T; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
Raitakari O; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
Kähönen M; German Center for Diabetes Research (DZD), Munich, Germany.
Gylling H; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764, Neuherberg, Germany.
Baber R; Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians University of Munich, Munich, Germany.
Isermann B; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, 55101, Mainz, Germany.
Stumvoll M; Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University Munich, 81377, Munich, Germany.
Loeffler M; Medical Department III - Endocrinology, Nephrology, Rheumatology, University Hospital Leipzig, Leipzig, Germany.
März W; German Center for Diabetes Research (DZD), Munich, Germany.
Meitinger T; Medical Department III - Endocrinology, Nephrology, Rheumatology, University Hospital Leipzig, Leipzig, Germany.
Peters A; Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland.
Thiery J; Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33521, Finland.
Teupser D; Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33521, Finland.
Ceglarek U; Heart and Lung Center, Cardiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Nat Commun ; 13(1): 143, 2022 01 10.

Article em En | MEDLINE | ID: mdl-35013273

Assuntos

Colesterol/sangue; Doença da Artéria Coronariana/genética; Loci Gênicos; Metabolismo dos Lipídeos/genética; Fitosteróis/sangue; Sistema ABO de Grupos Sanguíneos/sangue; Sistema ABO de Grupos Sanguíneos/genética; Membro 5 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/sangue; Membro 5 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/genética; Membro 8 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/sangue; Membro 8 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/genética; Adulto; Apolipoproteínas E/sangue; Apolipoproteínas E/genética; Doença da Artéria Coronariana/sangue; Doença da Artéria Coronariana/patologia; Feminino; Regulação da Expressão Gênica; Predisposição Genética para Doença; Estudo de Associação Genômica Ampla; Humanos; Hidroximetilglutaril-CoA Redutases/sangue; Hidroximetilglutaril-CoA Redutases/genética; Lipase/sangue; Lipase/genética; Lipoproteínas/sangue; Lipoproteínas/genética; Masculino; Proteínas de Membrana Transportadoras/sangue; Proteínas de Membrana Transportadoras/genética; Análise da Randomização Mendeliana; Herança Multifatorial; Polimorfismo de Nucleotídeo Único; Receptores Depuradores Classe B/sangue; Receptores Depuradores Classe B/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fitosteróis / Doença da Artéria Coronariana / Colesterol / Metabolismo dos Lipídeos / Loci Gênicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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