Drug Treatment of Low Bone Mass and Other Bone Conditions in Pediatric Patients.
Paediatr Drugs
; 24(2): 103-119, 2022 Mar.
Article
em En
| MEDLINE
| ID: mdl-35013997
ABSTRACT
Osteoporosis may affect young individuals, albeit infrequently. In childhood, bone mass increases, reaching its peak between the second and third decades; then, after a period of stability, it gradually declines. Several conditions, including genetic disorders, chronic diseases, and some medications, can have an impact on bone homeostasis. Diagnosis in young patients is based on the criteria defined by the International Society for Clinical Densitometry (ISCD), published in 2013. High risk factors should be identified and monitored. Often simple interventions aimed to eliminate the underlying cause, to minimize the negative bone effects linked to drugs, or to increase calcium and vitamin D intake can protect bone mass. However, in selected cases, pharmacological treatment should be considered. Bisphosphonates remain the main therapeutic agent for children with significant skeletal fragility and are also useful in a large number of other bone conditions. Denosumab, an anti-RANKL antibody, could become a potential alternative treatment. Clinical trials to evaluate the long-term effects and safety of denosumab in children are ongoing.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osteoporose
/
Conservadores da Densidade Óssea
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article