Kaempferol as a precursor for ubiquinone (coenzyme Q) biosynthesis: An atypical node between specialized metabolism and primary metabolism.
Curr Opin Plant Biol
; 66: 102165, 2022 04.
Article
em En
| MEDLINE
| ID: mdl-35026487
ABSTRACT
Ubiquinone (coenzyme Q) is a vital respiratory cofactor and liposoluble antioxidant. Studies have shown that plants derive approximately a quarter of 4-hydroxybenzoate, which serves as the direct ring precursor of ubiquinone, from the catabolism of kaempferol. Biochemical and genetic evidence suggests that the release of 4-hydroxybenzoate from kaempferol is catalyzed by heme-dependent peroxidases and that 3-O-glycosylations of kaempferol act as a negative regulator of this process. These findings not only represent an atypical instance of primary metabolite being derived from specialized metabolism but also raise the question as to whether ubiquinone contributes to the ROS scavenging and signaling functions already established for flavonols.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Ubiquinona
/
Quempferóis
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article