Base excess measured at hospital admission is useful for predicting diabetic ketoacidosis severity and resolution time in adult patients.
Diabetes Metab Syndr
; 16(1): 102385, 2022 Jan.
Article
em En
| MEDLINE
| ID: mdl-35026666
ABSTRACT
BACKGROUND AND AIMS:
This study aimed to identify the biochemical factors measured at hospital admission that could predict diabetes ketoacidosis (DKA) resolution time in adult patients. MATERIALS ANDMETHODS:
This retrospective study included 79 patients >18 years of age. Multivariate analyses were performed to determine which variables might predict DKA resolution time. Biochemical parameters between the two DKA resolution time groups were compared.RESULTS:
Using multiple linear regression models, acidosis time was found to decrease by 29 h if the pH value increased by one unit, 0.64 h if the base excess (BE) value increased by 1 mmol, and 1.09 h if the bicarbonate (HCO3-) value increased by 1 mmol. The biochemical parameters that differed between the two groups were pH, HCO3-, and BE. Patients with delayed resolution of DKA had a blood pH of 7.1 (±0.18), HCO3- of 5.1 mmol (2.9-11.6 mmol), and BE of -21.5 mmol (-28.2 to -14.4 mmol) at hospital admission.CONCLUSIONS:
Lower pH, HCO3-, and BE values at hospital admission may predict longer DKA resolution times in adult patients. In addition, BE may predict DKA severity.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Cetoacidose Diabética
/
Diabetes Mellitus
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article