Rewards of divergence in sequences, 3-D structures and dynamics of yeast and human spliceosome SF3b complexes.

Yazhini, Arangasamy; Sandhya, Sankaran; Srinivasan, Narayanaswamy.

Afiliação

Yazhini A; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, Karnataka, 560012, India.
Sandhya S; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, Karnataka, 560012, India.
Srinivasan N; Molecular Biophysics Unit, Indian Institute of Science, Bangalore, Karnataka, 560012, India.

Curr Res Struct Biol ; 3: 133-145, 2021.

Article em En | MEDLINE | ID: mdl-35028595

Palavras-chave

Allostery; BPS, branch-point sequence; Bact, activated B spliceosome assembly; Cryo-EM structure; Cryo-EM, cryo-electron microscopy; DOPE, discrete optimized protein energy; NMA, normal mode analysis; PDB, protein data bank; Protein dynamics; RMSD, root mean square deviation; RRM, RNA recognition motif; SF3b complex; SF3b1; SF3b1SF3b6−bound, SF3b1 bound to SF3b6; SF3b1iso, SF3b1 in isolation; SIP, square inner product; Spliceosome

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article