Quantitative Metaproteomics and Activity-based Protein Profiling of Patient Fecal Microbiome Identifies Host and Microbial Serine-type Endopeptidase Activity Associated With Ulcerative Colitis.

Thuy-Boun, Peter S; Wang, Ana Y; Crissien-Martinez, Ana; Xu, Janice H; Chatterjee, Sandip; Stupp, Gregory S; Su, Andrew I; Coyle, Walter J; Wolan, Dennis W

Thuy-Boun, Peter S; Wang, Ana Y; Crissien-Martinez, Ana; Xu, Janice H; Chatterjee, Sandip; Stupp, Gregory S; Su, Andrew I; Coyle, Walter J; Wolan, Dennis W.

Afiliação

Thuy-Boun PS; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.
Wang AY; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.
Crissien-Martinez A; Scripps Green Hospital Division of Gastroenterology, La Jolla, California, USA.
Xu JH; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.
Chatterjee S; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.
Stupp GS; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Su AI; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.
Coyle WJ; Scripps Green Hospital Division of Gastroenterology, La Jolla, California, USA.
Wolan DW; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA. Electronic address: wolan@scripps.edu.

Mol Cell Proteomics ; 21(3): 100197, 2022 03.

Article em En | MEDLINE | ID: mdl-35033677

Assuntos

Colite Ulcerativa; Microbiota; Cromatografia Líquida; Colite Ulcerativa/diagnóstico; Colite Ulcerativa/microbiologia; Endopeptidases; Fezes/microbiologia; Humanos; RNA Ribossômico 16S/genética; Serina; Espectrometria de Massas em Tandem

Palavras-chave

ABPP; ComPIL; activity-based protein profiling; chemoproteomics; de novo peptide sequencing; fluorophosphonate; microbiome metaproteomics; ulcerative colitis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colite Ulcerativa / Microbiota Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colite Ulcerativa / Microbiota Idioma: En Ano de publicação: 2022 Tipo de documento: Article