Anti-GPVI (HY101) activates platelets in a multicolor flow cytometry panel.
Platelets
; 33(7): 1096-1099, 2022 Oct 03.
Article
em En
| MEDLINE
| ID: mdl-35037555
ABSTRACT
The platelet transmembrane receptor GPVI can be assessed together with other platelet membrane markers in a whole blood multicolor flow cytometry panel. The advantage of combining multiple antibodies in a single tube is the possibility of distinguishing multiple platelet subgroups. In this short communication, we describe an activation problem encountered with anti-GPVI, clone HY101. Activation of platelets was seen after the addition of anti-GPVI in a flow cytometry panel, highlighted by the expression of the activation markers CD62P, PAC-1, CD63, and CD107a. This was also confirmed by platelet aggregation studies.
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MEDLINE
Assunto principal:
Plaquetas
/
Glicoproteínas da Membrana de Plaquetas
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article