Optical properties of human brain and tumour tissue: An ex vivo study spanning the visible range to beyond the second near-infrared window.
J Biophotonics
; 15(4): e202100072, 2022 04.
Article
em En
| MEDLINE
| ID: mdl-35048541
ABSTRACT
Neuro-oncology surgery would benefit from detailed intraoperative tissue characterization provided by noncontact, contrast-agent-free, noninvasive optical imaging methods. In-depth knowledge of target tissue optical properties across a wide-wavelength spectrum could inform the design of optical imaging and computational methods to enable robust tissue analysis during surgery. We adapted a dual-beam integrating sphere to analyse small tissue samples and investigated ex vivo optical properties of five types of human brain tumour (meningioma, pituitary adenoma, schwannoma, low- and high-grade glioma) and nine different types of healthy brain tissue across a wavelength spectrum of 400 to 1800 nm. Fresh and frozen tissue samples were analysed. All tissue types demonstrated similar absorption spectra, but the reduced scattering coefficients of tumours show visible differences in the obtained optical spectrum compared to those of surrounding normal tissue. These results underline the potential of optical imaging technologies for intraoperative tissue characterization.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
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Glioma
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Neoplasias Meníngeas
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Meningioma
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article