The GLT-1 enhancer clavulanic acid suppresses cocaine place preference behavior and reduces GCPII activity and protein levels in the rat nucleus accumbens.

Philogene-Khalid, Helene L; Morrison, Mary F; Darbinian, Nune; Selzer, Michael E; Schroeder, Joseph; Rawls, Scott M

Philogene-Khalid, Helene L; Morrison, Mary F; Darbinian, Nune; Selzer, Michael E; Schroeder, Joseph; Rawls, Scott M.

Afiliação

Philogene-Khalid HL; Department of Neural Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA; Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address: helene.khalid@tuhs.temple.edu.
Morrison MF; Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA; Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Darbinian N; Department of Neural Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA; Center for Neural Repair and Rehabilitation (Shriners Hospitals Pediatric Research Center), Department of Neurology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Selzer ME; Department of Neural Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA; Center for Neural Repair and Rehabilitation (Shriners Hospitals Pediatric Research Center), Department of Neurology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Schroeder J; Behavioral Neuroscience Program, Connecticut College, New London, CT, USA.
Rawls SM; Department of Neural Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA; Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.

Drug Alcohol Depend ; 232: 109306, 2022 03 01.

Article em En | MEDLINE | ID: mdl-35051699

Assuntos

Transtornos Relacionados ao Uso de Cocaína; Cocaína; Animais; Ácido Clavulânico/metabolismo; Ácido Clavulânico/farmacologia; Transtornos Relacionados ao Uso de Cocaína/tratamento farmacológico; Transtornos Relacionados ao Uso de Cocaína/metabolismo; Transportador 2 de Aminoácido Excitatório/metabolismo; Transportador 2 de Aminoácido Excitatório/farmacologia; Núcleo Accumbens; Ratos

Palavras-chave

Addiction; Clavulanic acid (CLAV); Cocaine; Conditioned place preference; GCPII; GLT-1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cocaína / Transtornos Relacionados ao Uso de Cocaína Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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