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Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity.
Sakurai, Fumie; Yukawa, Takafumi; Kina, Asato; Murakami, Masataka; Takami, Kazuaki; Morimoto, Sachie; Seto, Masaki; Kamata, Makoto; Yamashita, Tohru; Nakashima, Kosuke; Narita, Naohiro; Bettini, Ezio; Ugolini, Annarosa; Corsi, Mauro; Hasui, Tomoaki.
Afiliação
  • Sakurai F; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Yukawa T; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Kina A; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Murakami M; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Takami K; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Morimoto S; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Seto M; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Kamata M; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Yamashita T; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Nakashima K; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Narita N; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Bettini E; Aptuit, an Evotec Company, Via A. Fleming 4, 37135 Verona, Italy.
  • Ugolini A; Aptuit, an Evotec Company, Via A. Fleming 4, 37135 Verona, Italy.
  • Corsi M; Aptuit, an Evotec Company, Via A. Fleming 4, 37135 Verona, Italy.
  • Hasui T; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: tomoaki.hasui@takeda.com.
Bioorg Med Chem ; 56: 116576, 2022 02 15.
Article em En | MEDLINE | ID: mdl-35051811
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Receptores de N-Metil-D-Aspartato / Receptores de AMPA / Descoberta de Drogas Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Receptores de N-Metil-D-Aspartato / Receptores de AMPA / Descoberta de Drogas Idioma: En Ano de publicação: 2022 Tipo de documento: Article