Humoral immunity in hepatitis B virus infection: Rehabilitating the B in HBV.

Vanwolleghem, Thomas; Adomati, Tom; Van Hees, Stijn; Janssen, Harry L A.

Afiliação

Vanwolleghem T; Department of Gastroenterology and Hepatology, Antwerp University Hospital, 2650 Antwerp, Belgium.
Adomati T; Viral Hepatitis Research Group, Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, 2650 Antwerp, Belgium.
Van Hees S; Department of Gastroenterology and Hepatology, Antwerp University Hospital, 2650 Antwerp, Belgium.
Janssen HLA; Viral Hepatitis Research Group, Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, 2650 Antwerp, Belgium.

JHEP Rep ; 4(2): 100398, 2022 Feb.

Article em En | MEDLINE | ID: mdl-35059620

Palavras-chave

ADCC, antibody-dependent cellular cytotoxicity; ALT, alanine aminotransferase; AtMBCs, atypical memory B cells; B cells; CHB, chronic hepatitis B; DEGs, differentially expressed genes; ENEG, HBeAg-negative chronic hepatitis; Fcrl5, Fc receptor-like 5; HBV-ALF, HBV-induced acute liver failure; HBcAb, hepatitis B core antibodies; HBcrAg, hepatitis B core-related antigen; HBsAb, hepatitis B surface antibodies; HC, healthy controls; HbeAb, hepatitis B e antibodies; IL-, interleukin-; MBC, memory B cells; NA s, nucleos(t)ide analogues; ORF, open reading frame; PBMC, peripheral blood mononuclear cells; PD-1, programmed cell death 1; TLR, Toll-like receptor; antibodies; cccDNA, covalently closed circular DNA; flares; global B cells; hepatitis B virus; hepatitis B-specific B cells; iMATE, intrahepatic myeloid-cell aggregates

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article