Metabolomics reveals that fittest trail runners show a better adaptation of bioenergetic pathways.
J Sci Med Sport
; 25(5): 425-431, 2022 May.
Article
em En
| MEDLINE
| ID: mdl-35063356
ABSTRACT
OBJECTIVES:
To analyze the effect in the blood metabolome of trail running, a demanding sport that takes place in the natural environment, places considerable strain on both muscles and joints. While metabolic responses to aerobic exercise have been analyzed in-depth, few studies have focused on trail running.DESIGN:
Observational study to analyze changes in 35 different metabolites - representative of aerobic exercise-induced by a simulated 21-km trail race with an uphill gradient of 1400â¯m.METHODS:
We performed a semiquantitative metabolomics study consisting of capillary blood microsampling and targeted screening with liquid chromatography and mass spectrometry to analyze, in 33 licensed athletes, changes concerning 35 metabolites.RESULTS:
We observed significant changes in many metabolites, including increased acetyl-carnitine and taurine concentrations (false discovery rate-corrected paired t-test P value 1.63â¯×â¯10-13, and P value 5.021â¯×â¯10-12, respectively) and decreased carnitine and proline concentrations (P value 6.33â¯×â¯10-10, and P value 1.21â¯×â¯10-9, respectively). Metabolic responses to trail running were largely independent of sex but were influenced by the level of training, with runners with a higher level showing resistance to exercise-induced changes in taurine, 1-methyl histidine, acetyl-carnitine, and hypoxanthine concentrations. Performance (measured as race time) was inversely correlated with changes in specific metabolites (including taurine, serotonin, and hypoxanthine) and directly correlated with increases in glutathione.CONCLUSIONS:
Our findings demonstrate the usefulness of metabolomics studies for analyzing exercise-induced physiological changes and show individual differences associated with the level of training and performance.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Metabolismo Energético
/
Metabolômica
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article