Secretory pathway Ca<sup>2+</sup>-ATPase SPCA2 regulates mitochondrial respiration and DNA damage response through store-independent calcium entry.

Makena, Monish Ram; Ko, Myungjun; Mekile, Allatah X; Senoo, Nanami; Dang, Donna K; Warrington, John; Buckhaults, Phillip; Talbot, C Conover; Claypool, Steven M; Rao, Rajini

Secretory pathway Ca²⁺-ATPase SPCA2 regulates mitochondrial respiration and DNA damage response through store-independent calcium entry.

Makena, Monish Ram; Ko, Myungjun; Mekile, Allatah X; Senoo, Nanami; Dang, Donna K; Warrington, John; Buckhaults, Phillip; Talbot, C Conover; Claypool, Steven M; Rao, Rajini.

Afiliação

Makena MR; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ko M; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mekile AX; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Senoo N; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dang DK; Vanderbilt University, Nashville, TN, USA.
Warrington J; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.
Buckhaults P; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC, USA.
Talbot CC; Institute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Claypool SM; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rao R; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: rrao@jhmi.edu.

Redox Biol ; 50: 102240, 2022 04.

Article em En | MEDLINE | ID: mdl-35063802

Assuntos

Neoplasias da Mama; ATPases Transportadoras de Cálcio/genética; Cálcio; Dano ao DNA; Mitocôndrias; Adenosina Trifosfatases/genética; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Cálcio/metabolismo; Sinalização do Cálcio; ATPases Transportadoras de Cálcio/metabolismo; Feminino; Humanos; Mitocôndrias/genética; Mitocôndrias/metabolismo; Proteína ORAI1/genética; Proteína ORAI1/metabolismo; Respiração; Via Secretória

Palavras-chave

Ca(2+) signaling; DNA damage Response; Doxorubicin; ER+ breast cancer; Mitochondria; Oxygen consumption rate; ROS; p53

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Neoplasias da Mama / Cálcio / ATPases Transportadoras de Cálcio / Mitocôndrias Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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