Treatment of Severe Japanese Encephalitis Complicated With Hashimoto's Thyroiditis and Guillain-Barré Syndrome With Protein A Immunoadsorption: A Case Report.
Front Immunol
; 12: 807937, 2021.
Article
em En
| MEDLINE
| ID: mdl-35069593
ABSTRACT
A severely comatose female patient was diagnosed with Japanese encephalitis (JE). Her condition was complicated by Hashimoto's thyroiditis (HT) and Guillain-Barré syndrome (GBS). After antiviral, glucocorticoid, and immunoglobulin treatment, the patient's consciousness was restored, and she could breathe spontaneously. Following this, new-onset, primarily demyelinating GBS developed, which progressed to demyelination combined with axonal injury. The patient was switched to protein A immunoadsorption (PAIA) therapy, and her Hughes score decreased rapidly, from 4 to 1 after 6 months. This patient is the first to receive PAIA combined with an antiviral-glucocorticoid-immunoglobulin regimen to treat encephalitis, meningitis, HT, and GBS caused by JE infection, thereby reflecting the importance of clinical application of PAIA in the treatment of immunological complications of JE.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteína Estafilocócica A
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Plasmaferese
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Encefalite Japonesa
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Síndrome de Guillain-Barré
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Doença de Hashimoto
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article