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Distributional homogeneity and penetration depth assessment of antibiotic added by surface coating to pellets with mid Infrared imaging and multivariate curve resolution.
Bastidas, Camila Y; Del P Castillo, Rosario; Manuel Amigo, José; von Plessing, Carlos; Troncoso, José.
Afiliação
  • Bastidas CY; Departamento de Análisis Instrumental, Facultad de Farmacia, Universidad de Concepción, 4070386 Barrio Universitario s/n, Concepción, Chile; Laboratorio de Bioespectroscopía y Quimiometría, Centro de Biotecnología, Universidad de Concepción. 4070386 Barrio Universitario s/n, Concepción, Chile. Elect
  • Del P Castillo R; Departamento de Análisis Instrumental, Facultad de Farmacia, Universidad de Concepción, 4070386 Barrio Universitario s/n, Concepción, Chile; Laboratorio de Bioespectroscopía y Quimiometría, Centro de Biotecnología, Universidad de Concepción. 4070386 Barrio Universitario s/n, Concepción, Chile.
  • Manuel Amigo J; Ikerbasque, Basque Foundation for Science, María Díaz de Haro, 48013 Bilbao, Spain; Department of Analytical Chemistry, University of the Basque Country UPV/EHU, P.O. Box 644, 15 48080 Bilbao, Basque Country, Spain.
  • von Plessing C; Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepción. 4070386 Barrio Universitario s/n Concepción, Chile. Electronic address: cvonples@udec.cl.
  • Troncoso J; Cargill Chile Ltda, Colaco, Puerto Varas, Chile. Electronic address: jose_Troncoso@cargill.com.
Spectrochim Acta A Mol Biomol Spectrosc ; 271: 120864, 2022 Apr 15.
Article em En | MEDLINE | ID: mdl-35074673
ABSTRACT
Fourier Transform Mid Infrared with Attenuated Total Reflection Imaging (FTIR-ATR imaging) and Multivariate Curve Resolution with Alternating Least Squares (MCR-ALS) were used in a multiblock fashion to study the presence, distribution and penetration depth of very low concentrations of florfenicol (FF) in a complex matrix like feed pellets for salmonids. Images from the surface, at 150 µm deep and 200 µm deep from the surface were analyzed to certify the penetration power of FF added by surface coating methodology. Besides, the unique homogeneity index was calculated in order to evaluate the distributional homogeneity of each component. The results demonstrated the reliability of MCR-ALS in studying the distributional homogeneity of FF. It was demonstrated that FF remains mostly on the surface of the pellets with almost no penetration. The rest of the components of the pellets (oil, protein and carbohydrates) were also analyzed. These three nutrients are distributed on the three layers analyzed with a relatively homogeneous location, being carbohydrates (%H = 51 ± 3) the component with the best homogeneous distribution, unlike protein (%H = 45 ± 5), and oil (%H = 40 ± 7). This is the first publication where the penetration of an antibiotic, added with surface-coating to feed pellets, was analyzed with FTIR-ATR imaging and multivariate analysis, showing the contribution these analytical tools can make to the medicated feed industry.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antibacterianos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antibacterianos Idioma: En Ano de publicação: 2022 Tipo de documento: Article