A DNA-Based Two-Component Excitonic Switch Utilizing High-Performance Diarylethenes.
Angew Chem Int Ed Engl
; 61(13): e202117735, 2022 03 21.
Article
em En
| MEDLINE
| ID: mdl-35076154
ABSTRACT
Nucleosidic diarylethenes (DAEs) are an emerging class of photochromes but have rarely been used in materials science. Here, we have developed doubly methylated DAEs derived from 2'-deoxyuridine with high thermal stability and fatigue resistance. These new photoswitches not only outperform their predecessors but also rival classical non-nucleosidic DAEs. To demonstrate the utility of these new DAEs, we have designed an all-optical excitonic switch consisting of two oligonucleotides one strand containing a fluorogenic double-methylated 2'-deoxyuridine as a fluorescence donor and the other a tricyclic cytidine (tC) as acceptor, which together form a highly efficient conditional Förster-Resonance-Energy-Transfer (FRET) pair. The system was operated in liquid and solid phases and showed both strong distance- and orientation-dependent photochromic FRET. The superior ON/OFF contrast was maintained over up to 100 switching cycles, with no detectable fatigue.
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Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Transferência Ressonante de Energia de Fluorescência
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article