Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement.
Science
; 375(6583): 864-868, 2022 02 25.
Article
em En
| MEDLINE
| ID: mdl-35076256
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern evades antibody-mediated immunity that comes from vaccination or infection with earlier variants due to accumulation of numerous spike mutations. To understand the Omicron antigenic shift, we determined cryo-electron microscopy and x-ray crystal structures of the spike protein and the receptor-binding domain bound to the broadly neutralizing sarbecovirus monoclonal antibody (mAb) S309 (the parent mAb of sotrovimab) and to the human ACE2 receptor. We provide a blueprint for understanding the marked reduction of binding of other therapeutic mAbs that leads to dampened neutralizing activity. Remodeling of interactions between the Omicron receptor-binding domain and human ACE2 likely explains the enhanced affinity for the host receptor relative to the ancestral virus.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Evasão da Resposta Imune
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Glicoproteína da Espícula de Coronavírus
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Receptores de Coronavírus
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Enzima de Conversão de Angiotensina 2
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SARS-CoV-2
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Anticorpos Antivirais
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article