T-cell activation decreases miRNA-15a/16 levels to promote MEK1-ERK1/2-Elk1 signaling and proliferative capacity.

Urena, Frank; Ma, Chi; Hoffmann, FuKun W; Nunes, Lance G A; Urschitz, Johann; Moisyadi, Stefan; Khadka, Vedbar S; Deng, Youping; Hoffmann, Peter R

Urena, Frank; Ma, Chi; Hoffmann, FuKun W; Nunes, Lance G A; Urschitz, Johann; Moisyadi, Stefan; Khadka, Vedbar S; Deng, Youping; Hoffmann, Peter R.

Afiliação

Urena F; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA; Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Ma C; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
Hoffmann FW; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
Nunes LGA; Department of Anatomy, Physiology and Biochemistry, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
Urschitz J; Department of Anatomy, Physiology and Biochemistry, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
Moisyadi S; Department of Anatomy, Physiology and Biochemistry, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
Khadka VS; Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
Deng Y; Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
Hoffmann PR; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA. Electronic address: peterrh@hawaii.edu.

J Biol Chem ; 298(3): 101634, 2022 03.

Article em En | MEDLINE | ID: mdl-35085550

Assuntos

Sistema de Sinalização das MAP Quinases; MicroRNAs; Linfócitos T; Regiões 3' não Traduzidas; Animais; Ativação Linfocitária; MAP Quinase Quinase 1/genética; MAP Quinase Quinase 1/imunologia; MAP Quinase Quinase 1/metabolismo; Sistema de Sinalização das MAP Quinases/imunologia; Camundongos; MicroRNAs/genética; MicroRNAs/imunologia; MicroRNAs/metabolismo; Receptores de Antígenos de Linfócitos T/genética; Receptores de Antígenos de Linfócitos T/imunologia; Receptores de Antígenos de Linfócitos T/metabolismo; Linfócitos T/imunologia; Linfócitos T/metabolismo; Proteínas Elk-1 do Domínio ets/imunologia; Proteínas Elk-1 do Domínio ets/metabolismo

Palavras-chave

cell cycle; cell growth; cell signaling; miRNA; mitogen-activated protein kinase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Sistema de Sinalização das MAP Quinases / MicroRNAs Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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