Low untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90.
Alzheimers Dement
; 18(11): 2176-2187, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-35089640
ABSTRACT
INTRODUCTION:
We hypothesized that lower untreated systolic blood pressure (SBP) would be associated with a lower risk of dementia and death up to age 95.METHODS:
SBP measured between 2000 and 2006 was evaluated in relationship to dementia risk and brain biomarkers from 2009-2020 (n = 177) in the Gingko Evaluation of Memory Study (GEMS), mean age 95 in 2020. Participants had measurements of brain amyloid beta (Aß) and repeat clinical-cognitive evaluations every 6 months.RESULTS:
By 2020, only 9 of 177 patients (5%) were alive and cognitively unimpaired (CU). Mean SBP from 2000 to 2006 was 120 mm Hg for nine alive/CU, 125 mm Hg for alive/mild cognitive impairment (MCI), and 130 mm Hg for alive/dementia (P = .03). The amount of Aß was directly related to SBP levels. In multivariate analysis, Aß+ in 2009 and thinner cortex were significant predictors of dementia. Excluding Aß, SBP became a significant predictor of dementia.DISCUSSION:
Low SBP untreated by antihypertensive medications was associated with significant decreased risk of dementia and less Aß.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Demência
/
Doença de Alzheimer
/
Disfunção Cognitiva
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article