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Angiotensin-(1-7) ameliorates high glucose-induced vascular endothelial injury through suppressing chloride channel 3.
Cheng, Fei; Liu, Jing; Guo, Zhuolin; Li, Shicheng; Chen, Jingfu; Tu, Chang; Fu, Fengzhou; Shen, Bai; Zhang, Xiaojie; Lai, Guohua; Lan, Jun.
Afiliação
  • Cheng F; Second Ward of Cardiovascular Medicine, Dongguan Songshan Lake Center Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan City, Guangdong Province, China.
  • Liu J; Dongguan Cardiovascular Institute, Dongguan Third People's Hospital, Dongguan City, Guangdong Province, China.
  • Guo Z; Second Ward of General Pediatrics, Dongguan Eighth People's Hospital, Dongguan Children's Hospital, Dongguan City, Guangdong Province, China.
  • Li S; Dongguan Cardiovascular Institute, Dongguan Third People's Hospital, Dongguan City, Guangdong Province, China.
  • Chen J; Second Ward of Cardiovascular Medicine, Dongguan Songshan Lake Center Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan City, Guangdong Province, China.
  • Tu C; Second Ward of Cardiovascular Medicine, Dongguan Songshan Lake Center Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan City, Guangdong Province, China.
  • Fu F; Dongguan Cardiovascular Institute, Dongguan Third People's Hospital, Dongguan City, Guangdong Province, China.
  • Shen B; Second Ward of Cardiovascular Medicine, Dongguan Songshan Lake Center Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan City, Guangdong Province, China.
  • Zhang X; Second Ward of Cardiovascular Medicine, Dongguan Songshan Lake Center Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan City, Guangdong Province, China.
  • Lai G; Second Ward of Cardiovascular Medicine, Dongguan Songshan Lake Center Hospital, Affiliated Dongguan Shilong People's Hospital of Southern Medical University, Dongguan City, Guangdong Province, China.
  • Lan J; Dongguan Cardiovascular Institute, Dongguan Third People's Hospital, Dongguan City, Guangdong Province, China.
Bioengineered ; 13(2): 4100-4111, 2022 02.
Article em En | MEDLINE | ID: mdl-35098884
Diabetes Mellitus (DM) is a significant risk factor for cardiovascular disease (CVD), which is leading cause of deaths in DM patients. However, there are limited effective medical therapies for diabetic CVD. Vascular endothelial injury caused by DM is a critical risk factor for diabetic CVD. Previous study has indicated that Angiotensin-(1-7) (Ang-(1-7)) may prevent diabetic CVD, whereas it is not clear that Ang-(1-7) whether attenuates diabetic CVD through suppressing vascular endothelial injury. In this study, we found that Ang-(1-7) alleviated high glucose (HG)-induced endothelial injury in bEnd3 cells. Moreover, Ang-(1-7) ameliorated HG-induced endothelial injury through downregulating chloride channel 3 (CIC-3) via Mas receptor. Furthermore, HG-induced CIC-3 enhanced reactive oxygen species (ROS) and cytokine production and reduced the level of nitric oxide (NO), while Ang-(1-7) preserved the impact of HG-induced CIC-3 on productions of ROS, cytokine and NO through inhibiting CIC-3 via Mas receptor. Summarily, the present study revealed that Ang-(1-7) alleviated HG-induced vascular endothelial injury through the inhibition of CIC-3, suggested that Ang-(1-7) may preserve diabetic CVD through suppressing HG-induced vascular endothelial injury.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Angiotensina I / Endotélio Vascular / Canais de Cloreto / Glucose Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Angiotensina I / Endotélio Vascular / Canais de Cloreto / Glucose Idioma: En Ano de publicação: 2022 Tipo de documento: Article