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PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.
Khadka, Prasidda; Reitman, Zachary J; Lu, Sophie; Buchan, Graham; Gionet, Gabrielle; Dubois, Frank; Carvalho, Diana M; Shih, Juliann; Zhang, Shu; Greenwald, Noah F; Zack, Travis; Shapira, Ofer; Pelton, Kristine; Hartley, Rachel; Bear, Heather; Georgis, Yohanna; Jarmale, Spandana; Melanson, Randy; Bonanno, Kevin; Schoolcraft, Kathleen; Miller, Peter G; Condurat, Alexandra L; Gonzalez, Elizabeth M; Qian, Kenin; Morin, Eric; Langhnoja, Jaldeep; Lupien, Leslie E; Rendo, Veronica; Digiacomo, Jeromy; Wang, Dayle; Zhou, Kevin; Kumbhani, Rushil; Guerra Garcia, Maria E; Sinai, Claire E; Becker, Sarah; Schneider, Rachel; Vogelzang, Jayne; Krug, Karsten; Goodale, Amy; Abid, Tanaz; Kalani, Zohra; Piccioni, Federica; Beroukhim, Rameen; Persky, Nicole S; Root, David E; Carcaboso, Angel M; Ebert, Benjamin L; Fuller, Christine; Babur, Ozgun; Kieran, Mark W.
Afiliação
  • Khadka P; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02215, USA.
  • Reitman ZJ; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Lu S; Harvard Biological and Biomedical Sciences PhD Program, Harvard University, Cambridge, MA, 02138, USA.
  • Buchan G; Department of Radiation Oncology, Duke University, Durham, NC, 27710, USA.
  • Gionet G; Duke Cancer Institute, Duke University, Durham, NC, 27710, USA.
  • Dubois F; The Preston Robert Tisch Brain Tumor Center at Duke, Duke University, Durham, NC, 27710, USA.
  • Carvalho DM; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.
  • Shih J; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.
  • Zhang S; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.
  • Greenwald NF; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02215, USA.
  • Zack T; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Shapira O; Division of Molecular Pathology, Institute of Cancer Research, London, UK.
  • Pelton K; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Hartley R; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Bear H; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02215, USA.
  • Georgis Y; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02215, USA.
  • Jarmale S; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02215, USA.
  • Melanson R; Department of Oncologic Pathology, Dana Farber Cancer Institute, Boston, MA, 02215, USA.
  • Bonanno K; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, 45267, USA.
  • Schoolcraft K; Research in Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45267, USA.
  • Miller PG; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.
  • Condurat AL; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.
  • Gonzalez EM; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Qian K; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Morin E; Department of Oncologic Pathology, Dana Farber Cancer Institute, Boston, MA, 02215, USA.
  • Langhnoja J; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Lupien LE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
  • Rendo V; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.
  • Digiacomo J; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Wang D; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.
  • Zhou K; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.
  • Kumbhani R; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.
  • Guerra Garcia ME; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, 45267, USA.
  • Sinai CE; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.
  • Becker S; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02215, USA.
  • Schneider R; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.
  • Vogelzang J; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.
  • Krug K; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.
  • Goodale A; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, 02215, USA.
  • Abid T; Duke Cancer Institute, Duke University, Durham, NC, 27710, USA.
  • Kalani Z; Department of Oncologic Pathology, Dana Farber Cancer Institute, Boston, MA, 02215, USA.
  • Piccioni F; Department of Oncologic Pathology, Dana Farber Cancer Institute, Boston, MA, 02215, USA.
  • Beroukhim R; Department of Oncologic Pathology, Dana Farber Cancer Institute, Boston, MA, 02215, USA.
  • Persky NS; Department of Oncologic Pathology, Dana Farber Cancer Institute, Boston, MA, 02215, USA.
  • Root DE; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Carcaboso AM; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Ebert BL; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Fuller C; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Babur O; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
  • Kieran MW; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02215, USA.
Nat Commun ; 13(1): 604, 2022 02 01.
Article em En | MEDLINE | ID: mdl-35105861
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oncogenes / Proteína Fosfatase 2C / Glioma / Mutação Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oncogenes / Proteína Fosfatase 2C / Glioma / Mutação Idioma: En Ano de publicação: 2022 Tipo de documento: Article