Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.

Gruijs da Silva, Lara A; Simonetti, Francesca; Hutten, Saskia; Riemenschneider, Henrick; Sternburg, Erin L; Pietrek, Lisa M; Gebel, Jakob; Dötsch, Volker; Edbauer, Dieter; Hummer, Gerhard; Stelzl, Lukas S; Dormann, Dorothee

Gruijs da Silva, Lara A; Simonetti, Francesca; Hutten, Saskia; Riemenschneider, Henrick; Sternburg, Erin L; Pietrek, Lisa M; Gebel, Jakob; Dötsch, Volker; Edbauer, Dieter; Hummer, Gerhard; Stelzl, Lukas S; Dormann, Dorothee.

Afiliação

Gruijs da Silva LA; Biocenter, Institute of Molecular Physiology, Johannes Gutenberg-Universität (JGU), Mainz, Germany.
Simonetti F; Graduate School of Systemic Neurosciences (GSN), Planegg-Martinsried, Germany.
Hutten S; Biocenter, Institute of Molecular Physiology, Johannes Gutenberg-Universität (JGU), Mainz, Germany.
Riemenschneider H; Graduate School of Systemic Neurosciences (GSN), Planegg-Martinsried, Germany.
Sternburg EL; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Pietrek LM; Biocenter, Institute of Molecular Physiology, Johannes Gutenberg-Universität (JGU), Mainz, Germany.
Gebel J; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Dötsch V; Biocenter, Institute of Molecular Physiology, Johannes Gutenberg-Universität (JGU), Mainz, Germany.
Edbauer D; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
Hummer G; Institute for Biophysical Chemistry, Goethe-Universität, Frankfurt am Main, Germany.
Stelzl LS; Institute for Biophysical Chemistry, Goethe-Universität, Frankfurt am Main, Germany.
Dormann D; Graduate School of Systemic Neurosciences (GSN), Planegg-Martinsried, Germany.

EMBO J ; 41(8): e108443, 2022 04 19.

Article em En | MEDLINE | ID: mdl-35112738

Assuntos

Esclerose Lateral Amiotrófica; Demência Frontotemporal; Esclerose Lateral Amiotrófica/genética; Esclerose Lateral Amiotrófica/metabolismo; Proteínas de Ligação a DNA/metabolismo; Humanos; Agregados Proteicos; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo

Palavras-chave

RNA-binding protein; TDP-43; neurodegeneration; phase separation; phosphorylation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Demência Frontotemporal / Esclerose Lateral Amiotrófica Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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